For example, the systemic and transgenic administration of the soluble TGF-β RII/Fc dimer that binds all 3 TGF-β isoforms, reduced the tumor burden as well as intravasation and metastasis in tumor animal models and in transgenic breast cancer mammary tumor virus (MMTV)-neu mice models, respectively (29). This evidence concerns the gene TGFB1 and breast carcinoma.