SEMA4D and coronary artery disorder: Two genome-wide significant SNPs were found within the SHC3 gene, which is not known to be associated with CHD-related traits, however, within 1 Mb of this gene, there were several functional candidate genes, associated with bone formation or mineralization (SEMA4D, OMD, OGN), cartilage formation (PHF2), and differentiation into joint versus cartilage cells (BARX1).