Two genome-wide significant SNPs were found within the SHC3 gene, which is not known to be associated with CHD-related traits, however, within 1 Mb of this gene, there were several functional candidate genes, associated with bone formation or mineralization (SEMA4D, OMD, OGN), cartilage formation (PHF2), and differentiation into joint versus cartilage cells (BARX1). The gene discussed is PHF2; the disease is coronary artery disorder.