On one hand, NR4A1 behaves as a tumor suppressor by inhibiting growth of pancreatic cancer cells [27], and a double knock-out of NR4A1 and NR4A3 in mice was found to lead to the development of acute myeloid leukemia (AML); consistently, low expression of NR4A1 and NR4A3 has frequently been found in human AML [28], [29]. This evidence concerns the gene NR4A1 and acute myeloid leukemia.