AHR and asthma: Because both Ccl2 and Cxcl2 were reported to have a role in induction of AHR and chemoattraction of leukocyte in a mouse model of OVA-induced asthma [37]–[39], reduced production of these cytokines in bronchial epithelial cells may contribute to the alleviation of asthmatic phenotypes observed in PLCεΔX/ΔX mice.