miR-34a is a well recognized tumor suppressor gene in various cancer types, in which it can inhibit cell proliferation, induce cell apoptosis and senescence by targeting to CDK4/6, Cyclin E2, Cyclin D1, E2F3, Bcl-2, MYCN, Notch1/2 and SIRT1 [13], [14], [15], [16], and can inhibit cell migration and invasion by targeting c-Met, Notch1, Jagged1 and Fra-1 [14], [17], [18], [19]. Here, NOTCH1 is linked to cancer.