We noted that chronic administration of Isoproterenol did not further modify expression of S100A4, Vgl-4, Vgl-3, Mck and Bdnf. In addition, we found for the first time that beta adrenergic stimulation was sufficient to modulate the expression levels of S100a4, Vgl-3, Vgl-4 in WT animals, underlining their function in heart hypertrophy. The gene discussed is CKM; the disease is cardiac hypertrophy.