Moreover, diabetic mice with hippocampus-specific knockdown of GIGYF2 expression (DM + shRNA group) showed less cognitive impairment and less pathological ultrastructure changes than other diabetic mice (DM and DM +0 groups), thus supporting the notion that GIGYF2 plays an important role in the development of diabetic encephalopathy. The gene discussed is GIGYF2; the disease is diabetic encephalopathy.