Previous studies have demonstrated that the expression level of IGF1 and IGF1R decreased in brain tissue of diabetes [42], [43], and disruption of the GIGYF2 gene in mice led to a decrease in IGF1-stimulated IGF1R tyrosine phosphorylation but an augmentation in ERK1/2 phosphorylation [14]. The gene discussed is GIGYF2; the disease is diabetes mellitus.