However, when the test was performed again nine weeks later, the diabetic mice without shRNA injection (DM and DM +0 groups) performed more poorly than DM + shRNA and control groups (Fig. 5Ac and B), which was in accordance with the level of GIGYF2 expression in each group (Fig. 2A and 3A) and the changes in behavior and cognitive impairment in the experimental diabetes [36]. Here, GIGYF2 is linked to Cognitive impairment.