SLC31A1 and ovarian carcinoma: Always at a cellular level, studies of the pharmacology of cisplatin in human ovarian carcinoma A2780 cells, molecularly engineered to express increased hCtr1, showed that the overexpression of the transporter led to an increase in Pt accumulation and a decreased cell growth rate, yet it had limited effect on the sensitivity to cisplatin and to the amount of Pt binding to DNA [29].