CASP1 and neoplasm: At the 12th week, inflammasome loss of function decreased leukocytes infiltration into the tumor microenvironment [ASC-KO (2.1±0.7×106) and CASP-1-KO (1.4±0.3×106)], as compared to WT mice (2.75±0.16×106) (Fig. 2A).