Given the low alloreactivity of the rat NK cells to the human GBM cells, we interpret that dominant inhibitory signals might have been transduced when rodent Ly-49 recognized the class I HLA ligands on U87MG cells, in addition to the non-classical HLA-G and HLA-E, in the absence of NKG2D dependent activation signals. Here, KLRA1P is linked to glioblastoma.