However, in RAW 264.7 cells transduced with positive control shRNAs to knock down gene expression of IFN-γ receptor 1 (Ifngr1), 2 (Ifngr2) or Ticam2, the antiviral control by IFN-γ was greatly compromised and a 3- to 4-fold increase of infection efficiency was observed (Figure S2A and S2B). This evidence concerns the gene TICAM2 and infection.