GRB2 and cancer: The most significant genes included are FGFR2, the top finding in the original GWAS publication, and POLR1A genes (p-value < 10−4). The network is mainly centered in five genes, JAK2, MAP3K1, YWHAZ, GRB2 and MAPK1. From these 116 genes in Figure 4, we highlighted those 8 genes that achieved the highest score (present in the LCCs derived from both cancer datasets and in none of the other datasets analyzed) as the best candidates for harboring variants associated with cancer risk.