In two independent case-control studies, we firstly genotyped three putatively functional SNPs of PXR (i.e., rs3814055C>T in the 5'-untranslated region (5'-UTR); rs3732360C>T and rs3814058C>T in the 3'-untranslated region (3'-UTR)) with common frequency (i.e., minor allele frequency in Chinese > 5%) in a southern Chinese population with a total of 1056 cases of lung cancer patients and 1056 sex and age frequency-matched controls, and analyzed the associations between the SNPs and lung cancer risk; we then validated the promising association in an eastern Chinese population. Here, NR1I2 is linked to lung carcinoma.