BSG and metastatic malignant neoplasm in the lymph nodes: One study has demonstrated that the expression of COX-2 and CD147 is significantly increased in hypopharyngeal squamous cell carcinoma (HSCC) tissues compared to the adjacent epithelium, and these authors have also reported a strong correlation between COX-2, CD44v6 and CD147 expression and invasion and lymph node metastasis in HSCC that is associated with T classification, lymph node metastasis and clinical stage [116].