Many genome-wide association studies have uncovered over 30 common sequence variants influencing serum UA concentrations and/or gout in several genes, mostly in SLC2A9, SLC22A12 and ABCG2. However, the function characterization of the identified associated allelic variants for urate transporters URAT1 and GLUT9 was not studied. This evidence concerns the gene SLC22A12 and gout.