The aim of our study is to clarify the frequency, the role and the function effect of individual allelic variants of urate transporters SLC2A9 and SLC22A12 to the serum level of UA in a group of 250 Czech individuals (150 controls, 54 nonspecific hyperuricemics and 46 primary gout and/or primary asymptomatic hyperuricemia patients). This evidence concerns the gene SLC2A9 and gout.