The first identified apoptotic regulator, Bcl-2, was cloned from human follicular B cell lymphoma cells which nearly invariably have a chromosomal t(14;18) translocation, placing the Bcl-2 gene under the control of the powerful IgG heavy chain promoter [4], [5] with the consequence of elevated levels of Bcl-2 promoting increased cell survival [6]. The gene discussed is BCL2; the disease is B-cell non-Hodgkin lymphoma.