PTCH1 and nevoid basal cell carcinoma syndrome: Components of the Hh pathway are expressed in human lenses [30] and studies of patients with Gorlin syndrome, also known as basal cell nevus syndrome (BCNS; OMIM #109400), due to mutations in PTCH1, show that ∼26% have ophthalmic abnormalities, including Peter's anomaly, cataract [31]–[33] and microphthalmia [34].