BDNF and neuropathy: However, a recent study using genome wide studies and miRNA sequencing was able to identify three miRNAs that were differentially regulated in neuropathy: miR-30d-5p and miR-125b-5p, two major players in regulating the expression of TNF-α, brain-derived neurotrophic factor (BDNF) and signal transducer and activator of transcription (STAT)-3, as well as miR-379-5p, all closely associated with neuropathic pain [116].