Both mutations result in early truncation of the ANK1 protein, encoded by Ank1. Implicated in hereditary spherocytosis, an inherited form of hemolytic anemia, mouse erythrocytes harboring mutations in Ank1 exhibit increased resistance to P. chabaudi, a model of blood stage malaria, potentially due to parasite maturation impairment [127,128]. This evidence concerns the gene ANK1 and malaria.