Individuals with defects in the IL-12/IL-23 (IL-12β, IL-12Rβ1) and IFNγ (IFNγR1, IFNγR2, STAT1) pathways are in fact predisposed to Mendelian susceptibility to mycobacterial disease (MSMD) and/or disseminated Salmonella infection [139,140,141,142,143,144]. This evidence concerns the gene IFNG and Salmonella Infections.