Bevacizumab prevented FLT-1 mRNA upregulation induced by hyperglycaemia in DRG neuron monocultures (relative expression normalized to 18s 103±13 vs hg 165±23; relative expression normalized to cyclophilin A 165±39 vs hg 223±5; p<0.05) and increased FLT-1 protein in SC monocultures (183.6±41.8 p<0.05 vs hg 61±11). This evidence concerns the gene PPIA and Hyperglycemia.