At the same time, hyperglycaemia significantly decreased FLT-1 protein level in SC monocultures (relative protein expression 61±11 vs ctrl 100), whereas FLT-1 protein level remained unchanged in neuron monocultures (55±28 vs ctrl 100) and DRG co-cultures (168±92 vs ctrl 100). The gene discussed is FLT1; the disease is Hyperglycemia.