Hyperglycaemia significantly upregulated FLT-1 mRNA in DRG neuron monocultures (relative expression normalized to 18s 165±23 vs ctrl 100; relative expression normalized to actin 244±0.5 vs ctrl 100; relative expression normalized to cyclophilin A 223±5.1 vs ctrl 100; p<0.05), whereas it did not change its level in DRG co-cultures (131±32 vs ctrl 100) and SC monocultures (121±41 vs ctrl 100). The gene discussed is FLT1; the disease is Hyperglycemia.