A significant association between CXCL12 G801A polymorphism and cancer risk was found under an additive genetic model (OR = 1.30, 95% CI = 1.16–1.45), a dominant genetic model (OR = 1.37, 95%CI = 1.19–1.58), and a recessive genetic model (OR = 1.38, 95% CI = 1.13–1.69). Here, CXCL12 is linked to cancer.