Chen and colleagues demonstrated that cucurbitacin I (JSI-124), which is supposed to represent a potential chemo- and radio-sensitizer [97], decreased the expression level of pSTAT3Tyr705 in a subset of CD44+/ALDH1+ cells from HNSCC patient-derived tumors, which showed high levels of p-STAT3 and displayed typical properties of putative cancer stem cell (CSC) [91]. The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.