Moreover, Kang et al. showed that treatment with the natural flavonoid compound, xanthohumol, which decreases expression levels of STAT3 and epidermal growth factor receptor (EGFR), increased the sensitivity of MCF-7 human breast cancer cells, as well as doxorubicin-resistant MCF-7 cells by inducing apoptosis [57]. This evidence concerns the gene EGFR and breast carcinoma.