Therefore, the HAI-2 (SPINT2) gene is a candidate for a novel tumor suppressor, although further studies will be required to determine the regulatory roles of HAI-2 in pericellular activation of HGF/SF and induction of MET signaling, as well as to describe the effect of HAI-2 loss on MET signaling in cancer cells. The gene discussed is SPINT2; the disease is neoplasm.