EGFR and non-small cell lung carcinoma: FDG-PET/CT showed a high predictive value on treatment outcome when erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, was administered before radical surgery as neo-adjuvant treatment in NSCLC: in 70% of the metabolic responders tumor necrosis had occurred, whereas necrosis was observed in only 40% of the non responders at 1 week after therapy [213].