Only three global proteomic studies have been performed in airway epithelial cells which are one of the main targets in CF: two in lung epithelial cell lines IB3-1 (i.e. immortalized bronchial epithelial cell line isolated from a patient homozygous for the F508del mutation) and C38 (i.e. IB3-1 “corrected” by transfection with wild type CFTR) [8], [9] and the last one in cells obtained by nasal brushing (including blood, inflammatory and epithelial cells) from CF patients [10]. Here, CFTR is linked to cystic fibrosis.