Focusing on the cytoskeleton, we observed four proteins upregulated, keratins 6A, 14, 17 and 5 (K2C6A, K1C14, K1C17, K2C5) and three downregulated, ezrin (EZRI), tubulins alpha 1A and 4A (TBA1A and TBA4A) in CFNP and stable in NP compared to CTRL suggesting a cytoskeleton reshuffle in CF. This evidence concerns the gene EZR and cystic fibrosis.