In addition, the upregulation of cytoplasmic structural proteins in CF (K2C5, K1C14, K2C6A and K1C17) and the downregulation of TBA1A, TBA4A and EZRI, known to interact with CFTR by anchoring it to the tubulin cytoskeleton [40], [41], suggest a possible intracellular remodeling of airway epithelial cells that could be related to trafficking and/or stabilization processes. This evidence concerns the gene CFTR and cystic fibrosis.