Three proteins implicated in these pathways were significantly downregulated in CFNP compared to NP and CTRL, Rho GDP-dissociation inhibitor 1 (GDIR1), 14-3-3 proteins sigma and beta (1433S, 1433B), suggesting possible abnormalities in the ligand/receptor responsiveness in CF. The gene discussed is YWHAQ; the disease is cystic fibrosis.