Our objective was the determine the frequency of most common mutations in KRAS gene (p.G12D, p.G12V, p.G12A, p.G12C, p.G12S, p.G12R, p.G13D, p.Q61H, p.Q61L, p.Q61R, p.A146T, p.A146V, p.A146P) together with the BRAF V600E mutation in Albanian patients with metastatic colorectal cancer. This evidence concerns the gene BRAF and metastatic colorectal cancer.