In glioma, Shi et al. found that miR-124 inhibited glioma cell growth, invasion, angiogenesis, and tumor growth and increased chemosensitivity to TMZ treatment by negatively regulating the Ras family and its downstream signaling pathways: phosphatidylinositol-3 kinase/Akt and Raf/extracellular signal-regulated kinase 1/2 [25]. This evidence concerns the gene AKT1 and central nervous system cancer.