For example, higher expression of TFF3 was observed in invasive ductal carcinoma [15]; TFF3 expression was observed to be associated with the localization of metastatic MC cells to bone and to micrometastatic MC [16],[17]; TFF3 was included in a panel of four genes that specifically detected minimal residual disease in the circulation and consequently predicted worse survival in patients with metastatic MC [17]; and TFF3 has been used as a marker for the detection of disseminated MC cells together with TFF1 [18]. This evidence concerns the gene TFF3 and invasive ductal breast carcinoma.