Consistent with this, HOXA1 and HOXD10 are putative targets for miR-10a/b in Garzon et al. 2006 [34], suppression or overexpression of miR-10a/b increased or decreased HOXA1/HOXD10 protein expression, respectively, in breast cancer cell lines explained in Additional file 1: Figure S2, escalated in the silenced RUNX2 cells by 3.86 and 2.33 fold, respectively (Figure 2C). This evidence concerns the gene RUNX2 and breast carcinoma.