Consequently, new studies were planned to investigate: (i) whether other non-TC and non-macrophage cells in the enteric wall (mainly interstitial cell of Cajal: ICC) have this property, (ii) whether TCs show this uptake activity in other locations after interstitial release of endogenous or exogenous pigmented particles (hemosiderin, silver component of amalgam and melanin) and (iii) the differences between phTCs and CD68+ specialized phagocytic cells (CD68+ macrophages) after phagocytosis. This evidence concerns the gene CD68 and intrahepatic cholangiocarcinoma.