PLAU and infection: Immunodeficient mice transgenic for urokinase-type plasminogen activator transgene (uPa, SCID/ uPa mice) or knockout for fumarylacetoacetate hydrolase (Fah, FRG mice) transplanted with human hepatocytes have proven to sustain P. falciparum liver stage infection [11, 14, 15] and to transition toward blood stage infection upon exogenous injection of human erythrocytes [11].