Aberrant TAM signaling in human disease, most notably in cancer, is now a major research focus (Leconet et al., 2013; Meyer et al., 2013; Schlegel et al., 2013), and small-molecule TAM tyrosine kinase inhibitors and antibodies that inhibit TAM ligand–receptor binding are in development as cancer therapies (Holland et al., 2010; Ye et al., 2010; Brandao et al., 2011; Schlegel et al., 2013; Paccez et al., 2014). This evidence concerns the gene STIM1 and cancer.