TXN and atherosclerosis: However, this increment was substantially higher in LCA of NLS-Trx1 Tg than WT [WT-RCA (37.4±1.6 μm), WT-LCA (54.8±1.4 μm), Tg-RCA (35.0±2.3 μm), Tg-LCA (66.0±3.0 μm)] (Fig. 1) and also Oil red O staining showed evidence of increased fat accumulation contributing to atherosclerosis development in Tg compared to WT mice.