To determine whether potentiation of atherogenic events, increased wall thickening observed in NLS-Trx1 Tg by disturbed flow, was associated with other risk factors for atherosclerosis such as high cholesterol level and obesity, WT and Tg mice that underwent LCA ligation and fed high fat diet for 8 weeks were examined for lipid levels and body weight. This evidence concerns the gene TXN and obesity due to melanocortin 4 receptor deficiency.