qRT-PCR data showed that miR-135b was dramatically elevated in the recurrent tumors compared to the primary tumors after IR treatment, but the mRNA expression of GSK3β was dramatically declined in the recurrent tumors compared to the primary tumors after IR treatment (p<0.01, Figure 5E, F), indicating that the glioma cells with high expression of miR-135b or GSK3β were more resistant to the IR and more susceptible to death, whereas the glioma cells with low miR-135b or GSK3β levels were more sensitive to IR. This evidence concerns the gene GSK3B and central nervous system cancer.