Therefore, the objectives of the present study were 1. to investigate the local, including non-neuronal mRNA expression level and protein localization of TRPA1 in comparison with the TRPV1 in the intact and inflamed mouse distal colon and colon biopsy samples of IBD patients; 2. to study the role of TRPA1 in DSS-colitis using gene-deleted mice and analyzing the TRPA1-mediated changes in cytokine, neuropeptide and neuropeptide receptor expressions. Here, TRPV1 is linked to colitis.