In conclusion, the newly developed CKD-EPI cystatin C and combined CKD-EPI creatinine-cystatin C-derived eGFR equations were not superior in predicting CVD events or all-cause mortality compared with the commonly used CKD-EPI creatinine-derived eGFR equation in older female subjects with no or early CKD and this data cannot be extrapolated to older individuals with more advanced CKD. The gene discussed is CST3; the disease is chronic kidney disease.