CST3 and chronic kidney disease: A recent meta-analysis of sixteen population cohorts reported both CKD-EPI cystatin C and combined CKD-EPI creatinine-cystatin C equations improved the accuracy in predicting all-cause and CVD mortality compared to CKD-EPI creatinine equation, but the majority of the included population cohorts were younger individuals of mixed gender with dissimilar proportion of muscle mass [12].