For the prediction of CVD hospitalization and/or mortality, the AUCs varied between 0.660 (95%CI 0.622, 0.712), 0.659 (95%CI 0.621, 0.710; Sidak p-value 0.974) and 0.660 (95%CI 0.622, 0.712; Sidak p-value 0.996) respectively using the CKD-EPI creatinine, CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C equations adjusted for age, BMI, hypertension, diabetes, systolic blood pressure, prevalent renal disease and CVD, smoking history and treatment group (Figure 3). This evidence concerns the gene CST3 and diabetes mellitus.