Although the PPROM list of functional annotations is shorter and shows less significant p-values compared with sPTB, it has a distinct enrichment of functions related to lipid metabolism (triglycerides and fatty acids) and the lipid metabolic disorders such as hyperlipidemia, hypercholesterolemia (genes represented include HDL, LIPC and FAS) (Table S3). The gene discussed is FAS; the disease is familial hypercholesterolemia.