In PPROM however, inflammation component was related mainly to local organ inflammation with the highest scores p = 10−14 to p = 10−7 with the functions of ACE, AGT, CD14, COL4A3, COL4A4, FAS, IFNGR2, IGF1, MMP1 (includes EG:300339), NOS2, NOS3, REN, TNF. This evidence concerns the gene TNF and preterm premature rupture of the membranes.