In addition, PPROM inflammatory response is supported mainly by macrophages and especially phagocyte migration, activation and proliferation (AGT, CSF1 (includes EG:12977), FAS, TIMP2 (includes EG:21858), TNF, IL6R, CD14, TNFRSF1B). The gene discussed is TIMP2; the disease is preterm premature rupture of the membranes.