SPTB and familial hypercholesterolemia: Although the PPROM list of functional annotations is shorter and shows less significant p-values compared with sPTB, it has a distinct enrichment of functions related to lipid metabolism (triglycerides and fatty acids) and the lipid metabolic disorders such as hyperlipidemia, hypercholesterolemia (genes represented include HDL, LIPC and FAS) (Table S3).