Aquaporin 4 (AQP4), the main aqueduct in the brain, has emerged as an important target for in vivo and in vitro research focused on brain edema caused by ischemia [8], [9], intracerebral hemorrhage [10], brain trauma [11], hyponatremia [12], and hepatic encephalopathy [13]. This evidence concerns the gene AQP4 and brain injury.