FIS1 and Insulin resistance: Mitochondrial fission and its modulation by miRNA has also been shown in some metabolic conditions; miR-484 downregulation may contribute to the pathogenesis of Insulin resistance by targeting mitochondrial fission protein 1 (Fis1), which is needed for mitochondrial fission [61], as mitochondrial fission is increased in diabetes and contributes to circulating insulin levels [62].