For this purpose, we studied general blood cell parameters, peripheral HbF levels, and genotype at the three main HbF modifier loci, BCL11A, HMIP‐2, and Xmn1‐HBG2, in 726 Tanzanian SCD patients, who have minimal disease intervention such as regular blood transfusion or hydroxyurea therapy. This evidence concerns the gene HBG2 and Schnyder corneal dystrophy.