For instance, mutated TRIM32 leads to limb-girdle muscular dystrophy type 2H [27]; mutations in TRIM18 (MID1) cause Opitz G/BBB syndrome [28]; and TRIM63/MuRF1 mutations result in hypertrophic cardiomyopathy [29]. This evidence concerns the gene MID1 and hypertrophic cardiomyopathy.