BIN1 and myotonic dystrophy: AMPH2 mRNA splicing is misregulated in skeletal muscle of myotonic dystrophy patients leading to the expression of amph2 lacking the phosphoinositide-binding (PI) domain encoded by exon 11, which is involved in the targeting of AMPH2 to triads (Lee et al, 2002; Fugier et al, 2011).