These results demonstrated that THBS2 could affect angiogenesis in gastric cancer, nevertheless, because of no correlation between MVD and prognosis in our samples, we suspected that higher THBS2 expression indicating longer survival was not merely through inhibiting angiogenesis of gastric cancer, other mechanisms such as regulating ECM remoulding [23] and proliferation rate of gastric cancer cells might also be the reasons that need further researches to explore. This evidence concerns the gene THBS2 and gastric cancer.