As shown in Figure 4E and D, in both MKN-45 and SGC-7901 cell lines, human umbilical vein endothelial cells (HUVECs) cultured with the medium from THBS2-overexpression gastric cancer cells showed significantly lower AngiogenicIndexCh1 than the negative control (P < 0.05 for MKN-45 cells and P < 0.001 for SGC-7901 cells, respectively ). The gene discussed is THBS2; the disease is gastric cancer.