One should not overlook highlighting the observed strong correlation between sCD40L and PAI-1 (r = 0.53115, p = 0.0005) as well as moderate correlation between ∆CD40L and ∆PAI-1 (r = 0.43109; p = 0.0097) in the group of morbid obesity patients, which may contribute to less complications of atherosclerosis, by antypromoting thrombus formation in ruptured plaque. The gene discussed is SERPINE1; the disease is morbid obesity.