One SNP, rs7659 within the APOD gene region, was associated with IS risk (OR = 1.11; 95% CI: 1.01-1.22; P = 0.038 when tested by univariate analysis, and OR = 1.12; 95% CI: 1.01-1.25; P = 0.029 when using multiple logistic regression analysis controlling for covariates age, gender, diabetes mellitus, hypertension and current smoking). Here, APOD is linked to hypertensive disorder.