The effect of Dp44mT on inhibiting the metastasis of HCC was attributed to its ability to markedly up-regulate NDRG2, a well-known anti-metastatic gene.[23, 36] The NDRG2 content was high in normal hepatocytes, decreased in noninvasive and primary HCC cells, and reached the lowest level in invasive HCC cells. This evidence concerns the gene NDRG2 and hepatocellular carcinoma.