A increase in gp130 signal and activation of STAT3 is a key tumor survival mechanism, and promotes tumor metastatic processes including EMT and resistance to apoptosis.[39, 40] Previous studies have demonstrated that activated STAT3 plays a critical role in hematogenous intrahepatic metastasis in an orthotopic implantation model of HCC.[41]. This evidence concerns the gene STAT3 and neoplasm.