GABBR1 and familial pancreatic carcinoma: We have previously reported that high doses of nicotine comparable to the blood nicotine levels in heavy smokers accelerated the progression of pancreatic cancer xenografts by increasing cell proliferation and that treatment of the mice with GABA in the drinking water blocked this effect via GABA-B-receptor (GABA-B-R)-mediated inhibition of cAMP-dependent pathways [7, 8].