Two months later the emergency admission, he received an endocrine evaluation that revealed mild hypothyroidism [TSH 5.5 mU/L, freeT3 1.7 pg/ml (n.v. 2.6-4.4), freeT4 0.8 ng/dl (n.v. 0.9-1.7)], low IGF1 levels [107 ng/ml (n.v.117-252)], normal adrenal function and, remarkably, severe hypogonadotropic hypogonadism [testosterone 1.3 ng/ml (n.v. 2.4-10.0), LH 0.6 mU/ml, FSH 1.1 mU/ml]. The gene discussed is IGF1; the disease is hypothyroidism.