CRP and Sepsis: Multivariate linear regression analysis including APACHE-II score, SOFA score, CRP, white blood cells (WBC), creatinine, and platelet count as independent variables identified WBC (P <0.05, R2 = 0.64) and SOFA score (P <0.05, R2 = 0.64) as predictors for histone levels at onset of sepsis (day 1).