Indeed, some bridge proteins, including caspase 8, apoptosis-related cysteine peptidase (CASP8), p53 and catenin (cadherin-associated protein) beta 1, 88 kDa (CTNNB1, also known as β-catenin), showed high mutational frequencies in CRC samples, whereas sensor and enzymes proteins for BA metabolism did not [30]. The gene discussed is TP53; the disease is colorectal carcinoma.